Thioredoxin Polyclonal Antibody
Product Specifications
Background
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55) .
Synonyms
TRX; TRDX; TRX1; Thioredoxin; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP; TXN
Gene ID
7295
Swiss Prot
P10599
Cellular Locus
Cytoplasm, Nucleus, Secreted
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
51-105/105
Target
Thioredoxin
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Thioredoxin
Applications
ELISA, IHC-P, IHC-F, IF, Flow-Cyt, ICC/IF
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:1000-5000), IHC-P (1:100-500), IHC-F (1:100-500), IF (1:100-500), Flow-Cyt (1µg/Test), ICC/IF (1:100)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
7295
Curated Selection
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