VUF10166

VUF10166 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB) . VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM[1].

Product Specifications

CAS Number

[155584-74-0]

UNSPSC

12352005

Hazard Statement

H301, H311, H331

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vuf10166.html

Concentration

10mM

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1CCN(C2=NC3=CC=CC=C3N=C2Cl)CC1

Molecular Formula

C13H15ClN4

Molecular Weight

262.74

Precautions

H301, H311, H331

References & Citations

[1]Thompson AJ, et al. VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors. J Pharmacol Exp Ther. 2012 May;341 (2) :350-9.