PPOH

PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. In addition, PPOH acts on CYP4A2 and CYP4A3 with the IC50 values of 22 μM and 6.5 μM, respectively[1]. PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[206052-01-9]

Product Name Alternative

BE-34776

UNSPSC

12352005

Target

COX; Cytochrome P450

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ppoh.html

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C#CCOC1=CC=CC=C1CCCCCC(O)=O

Molecular Formula

C15H18O3

Molecular Weight

246.30

References & Citations

[1]Melissa A VanAlstine, et al. Effects of acetylenic epoxygenase inhibitors on recombinant cytochrome p450s. Drug Metab Dispos. 2011 Jul;39 (7) :1221-6.