Plasminogen Polyclonal Antibody
Product Specifications
Background
Plasminogen is a plasma protein synthesised mostly in the liver. Plasma concentration is usually in the range of 70 to 200mg/l. Plasminogen is activated by tissue plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Angiostatin, an internal fragment of plasminogen, is a potent inhibitor of angiogenesis, which selectively inhibits endothelial cell proliferation. Angiostatin potently inhibits tumor growth and can maintain metastatic and primary tumors in a dormant state. It is defined by a balance of proliferation and apoptosis of the tumor cells and is composed of plasminogen first four cringle structures. This molecule is generated by proteolytic cleavage of plasminogen.
Synonyms
Plasminogen; Angiostatin; DKFZp779M0222; Microplasmin; Plasmin; Plasmin heavy chain A; PLG; PLMN_HUMAN.
Gene ID
5340
Swiss Prot
P00747
Cellular Locus
Secreted, Cell membrane, Extracellular matrix
Host
Rabbit
Cross Reactivity
Human
Immunogen
251-350/810
Target
Plasminogen
Clonality
Polyclonal
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human PLG
Applications
WB, ELISA, IHC-P, IHC-F, IF
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (WB=1:500-2000), ELISA (ELISA=1:5000-10000), IHC-P (IHC-P=1:100-500), IHC-F (IHC-F=1:100-500), IF (IF=1:100-500)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Prediction Reactivity
Mouse, Rat, Dog, Cow, Pig
Gene ID URL
5340
Isotype
IgG
Curated Selection
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