Notch3 Polyclonal Antibody

Product Specifications

Background

NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (swissprot) .

Synonyms

HNotch 4; hNotch4; NOTCH 3; NOTCH3; INT 3; INT3; MGC74442; Neurogenic locus notch homolog protein 4; Neurogenic locus notch homolog protein 3; NOTC4_HUMAN; NOTCH-3; NOTCH-4; Notch 4 intracellular domain; Notch homolog 4; NOTCH4 protein; Neurogenic locus notch homolog protein 1; CADASIL; CASIL; Notch homolog 3.

Gene ID

4854

Cellular Locus

Nucleus, Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Immunogen

2001-2100/2318

Target

Notch3

Clonality

Polyclonal

Conjugation

Unconjugated

Source

KLH conjugated synthetic peptide derived from mouse Notch3

Applications

WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1ug/ul

Dilution

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Gene ID URL

4854

Isotype

IgG

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