TFRC Polyclonal Antibody
Product Specifications
Background
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Synonyms
Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; TFRC
Gene ID
7037
Swiss Prot
P02786
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse
Immunogen
21-120/760
Target
TFRC
Clonality
Polyclonal
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Transferrin receptor
Applications
ELISA, FCM
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
ELISA (1:500-1000), FCM (1:20-100)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Prediction Reactivity
Rat
Gene ID URL
7037
Isotype
IgG
Curated Selection
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