Shh Polyclonal Antibody
Product Specifications
Background
Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity) .
Synonyms
TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; Sonic hedgehog protein; SHH; HHG-1
Gene ID
6469
Swiss Prot
Q15465
Cellular Locus
Secreted, Cell membrane, Extracellular matrix
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
21-120/462
Target
Shh
Clonality
Polyclonal
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Shh
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Prediction Reactivity
Cow, Horse, Chicken, Rabbit
Gene ID URL
6469
Isotype
IgG
Curated Selection
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