UNC-2170 HCl
Product Specifications
Background
The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C
Product Datasheet
https://www.biossantibodies.com/datasheets/bs-82319C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1219246-01 0.02 mg (E-Coli)
Recombinant Staphylococcus aureus GMP reductase (guaC)
Ask
View Details 
MBS1219246-02 0.02 mg (Yeast)
Recombinant Staphylococcus aureus GMP reductase (guaC)
Ask
View Details MBS1219246-03 0.1 mg (E-Coli)
Recombinant Staphylococcus aureus GMP reductase (guaC)
Ask
View Details MBS1219246-04 0.1 mg (Yeast)
Recombinant Staphylococcus aureus GMP reductase (guaC)
Ask
View Details MBS1219246-05 0.02 mg (Baculovirus)
Recombinant Staphylococcus aureus GMP reductase (guaC)
Ask
View Details 
MBS1219246-06 0.02 mg (Mammalian-Cell)
Recombinant Staphylococcus aureus GMP reductase (guaC)
Ask
View Details