SP-600125

Selective inhibitor of c-Jun N-terminal kinase (JNK) . Reversibly inhibits JNK1,2 and 3 (IC50’s range from 40-90 nM) . >300-fold selectivity for JNK as compared to related MAP kinases. Antiinflammatory activity. Inhibits expression of presenilin-1 and Notch signaling in mouse brain. Cell permeable and active in vivo.