AURKC Antibody
Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.
Product Specifications
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
Q9UQB9
Host
Rabbit
Reactivity
Human
Immunogen
A portion of the C-terminal region of the human protein was used as immunogen for this AURKC antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Limitations
This AURKC antibody is available for research use only.
Storage Conditions
Aliquot the AURKC antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the AURKC antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of AURKC antibody and A375 cell lysate. Predicted molecular weight ~ 33 kDa.
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