ABCA6 Rabbit Polyclonal Antibody

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White) . This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24 and may play a role in macrophage lipid homeostasis. [provided by RefSeq, Jul 2008], developmental stage:Expressed in fetal kidney, lung and liver., function:Probable transporter which may play a role in macrophage lipid homeostasis., induction:Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages., similarity:Belongs to the ABC transporter family. ABCA subfamily., similarity:Contains 2 ABC transporter domains., tissue specificity:Widely expressed with higher expression in liver.