GRK 1 (phospho Ser21) Rabbit Polyclonal Antibody

This gene encodes a member of the guanine nucleotide-binding protein (G protein) -coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2) . [provided by RefSeq, Jul 2008], catalytic activity:ATP + [rhodopsin] = ADP + [rhodopsin] phosphate., disease:Defects in GRK1 are a cause of congenital stationary night blindness Oguchi type (CSNBO) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation., function:Phosphorylates rhodopsin thereby initiating its deactivation., online information:Retina International's Scientific Newsletter, PTM:Autophosphorylated., PTM:Farnesylation is required for full activity., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 protein kinase domain., similarity:Contains 1 RGS domain., tissue specificity:Retina and pineal gland.