TPH2 Rabbit Polyclonal Antibody
Product Specifications
Background
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016], catalytic activity:L-tryptophan + tetrahydrobiopterin + O (2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin., cofactor:Fe (2+) ion., disease:Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516]., pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2., similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family., similarity:Contains 1 ACT domain., tissue specificity:Brain specific.
Product Name Alternative
TPH2; NTPH; Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2
Gene Name
TPH2
Gene ID
121278
Swiss Prot
Q8IWU9
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, ELISA
Field of Research
Tryptophan metabolism
Purification
Affinity purification
Dilution
WB 1:500-1:2000, ELISA 1:20000-1:40000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
56kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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