ARHGAP9 Rabbit Polyclonal Antibody

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], function:GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix., similarity:Contains 1 PH domain., similarity:Contains 1 Rho-GAP domain., similarity:Contains 1 SH3 domain., similarity:Contains 1 WW domain., tissue specificity:Predominantly expressed in peripheral blood leukocytes, spleen, and thymus.