Nap1 Rabbit Polyclonal Antibody

AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011) -dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]) .[supplied by OMIM, Mar 2008], function:Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFN-beta promoter activation via TICAM1., subunit:Interacts with IKBKE, TBK1 and TICAM1., tissue specificity:Widely expressed. Abundant expression seen in the pancreas and testis.