PI 3-Kinase p110γ Rabbit Polyclonal Antibody

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015], catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate., enzyme regulation:Activated by both the alpha and the beta-gamma G proteins., function:3-phosphorylates the cellular phosphoinositide PtdIns-4,5-biphosphate (PtdIns (4,5) P2) to produce PtdIns-3, 4,5-triiphosphate (PtdIns (3,4,5) P3) . Links G-protein coupled receptor activation to the secondary messenger PtdIns (3,4,5) P3 production., pathway:Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis., similarity:Belongs to the PI3/PI4-kinase family., similarity:Contains 1 PI3K/PI4K domain., subunit:Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit., tissue specificity:Pancreas, skeletal muscle, liver and heart.

PIK3CG; Phosphatidylinositol 4; 5-bisphosphate 3-kinase catalytic subunit gamma isoform; PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit

Inositol phosphate metabolism; ErbB_HER; Chemokine; Phosphatidylinositol signaling system; mTOR; Apoptosis_Inhibition; Apoptosis_Mitochondrial; Apoptosis_Overview; VEGF; Focal adhesion; Toll_Like; Jak_STAT; Natural killer cell mediated cytotoxicity; T_Cell_Receptor; B_Cell_Antigen; Fc epsilon RI; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Neurotrophin; Regulates Actin and Cytoskeleton; Insulin_Receptor; Progesterone-mediated oocyte maturation; Type II diabetes mellitus; Aldosterone-regulated sodium reabsorption; Pathways in cancer; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer