EphB3 Rabbit Polyclonal Antibody

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010], catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., function:Receptor for members of the ephrin-B family. Binds to ephrin-B1 and -B2., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 SAM (sterile alpha motif) domain., similarity:Contains 2 fibronectin type-III domains., tissue specificity:Ubiquitous.