HLA-DOα Rabbit Polyclonal Antibody

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008], function:Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule., polymorphism:The only allele of DOA known is DOA*0101 which is shown here., similarity:Belongs to the MHC class II family., similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain., subunit:Heterodimer of an alpha chain (DOA) and a beta chain (DOB) .

Cell adhesion molecules (CAMs) ; Antigen processing and presentation; Intestinal immune network for IgA production; Type I diabetes mellitus; Asthma; Autoimmune thyroid disease; Systemic lupus erythematosus; Allograft rejection; Graft-versus-host disease; Viral myocarditis