HLA-DOβ Rabbit Polyclonal Antibody

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008], function:Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule., polymorphism:The following alleles of DOB are known: DOB*0101, DOB*0102, DOB*0103 and DOB*0104. The sequence shown is that of DOB*0101., similarity:Belongs to the MHC class II family., similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain., subunit:Heterodimer of an alpha chain (DOA) and a beta chain (DOB) .

Cell adhesion molecules (CAMs) ; Antigen processing and presentation; Intestinal immune network for IgA production; Type I diabetes mellitus; Asthma; Autoimmune thyroid disease; Systemic lupus erythematosus; Allograft rejection; Graft-versus-host disease; Viral myocarditis