PP2Cκ Rabbit Polyclonal Antibody

This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012], catalytic activity:A phosphoprotein + H (2) O = a protein + phosphate., caution:Ref.9 has crystallized PPM1K in the presence of magnesium ions. However, PubMed:17336929 reported that no activity toward p-nitrophenylphosphate was seen in the absence of manganese ions and magnesium could not subsitute for manganese., cofactor:Binds 1 magnesium or manganese ion per subunit., function:Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development., similarity:Belongs to the PP2C family., similarity:Contains 1 PP2C-like domain.

PPM1K; PP2CM; Protein phosphatase 1K; mitochondrial; PP2C domain-containing protein phosphatase 1K; PP2C-like mitochondrial protein; PP2C-type mitochondrial phosphoprotein phosphatase; PTMP; Protein phosphatase 2C isoform kappa; PP2C-kappa