NOS2 Rabbit Polyclonal Antibody

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008], catalytic activity:L-arginine + n NADPH + n H (+) + m O (2) = citrulline + nitric oxide + n NADP (+) ., cofactor:Binds 1 FAD., cofactor:Binds 1 FMN., cofactor:Heme group., cofactor:Tetrahydrobiopterin (BH4) . May stabilize the dimeric form of the enzyme., enzyme regulation:Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity., function:Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions., induction:By endotoxins and cytokines., online information:Nitric oxide synthase entry, similarity:Belongs to the NOS family., similarity:Contains 1 FAD-binding FR-type domain., similarity:Contains 1 flavodoxin-like domain., subunit:Homodimer. Binds SLC9A3R1., tissue specificity:Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.

NOS2; NOS2A; Nitric oxide synthase; inducible; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2