PI3 Kinase Class 3 Rabbit Monoclonal Antibody

Cell localization:Midbody . Late endosome . Cytoplasmic vesicle, autophagosome . As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358) . Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity) . ..catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate., cofactor:Manganese., function:Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes., similarity:Belongs to the PI3/PI4-kinase family., similarity:Contains 1 PI3K/PI4K domain., subunit:Probably forms a complex with AMBRA1 and BECN1 (By similarity) . Heterodimer. This subunit, part of a complex composed of regμLatory and catalytic subunits, associates with regμLatory subunit PIK3R4., tissue specificity:Ubiquitously expressed, with a highest expression in skeletal muscle.