VSPPLTLGQLLS (TFA)
Product Specifications
UNSPSC Description
VSPPLTLGQLLS TFA is a small peptide FGFR3 inhibitor, peptide P3, inhibits FGFR3 phosphorylation. VSPPLTLGQLLS TFA inhibits 9-cisRA-induced tracheal lymphangiogenesis and blocks lymphatic endothelial cell (LEC) proliferation, migration, and tubule formation[1][2].
Target Antigen
FGFR
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vsppltlgqlls-tfa.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H](C(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC(CNC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@H](CC(C)C)NC([C@H]1N(C([C@H]2N(C([C@H](CO)NC([C@H](C(C)C)N)=O)=O)CCC2)=O)CCC1)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
Molecular Weight
1338.47
References & Citations
[1]Perrault DP, et al. Small Peptide Modulation of Fibroblast Growth Factor Receptor 3-Dependent Postnatal Lymphangiogenesis. Lymphat Res Biol. 2019 Feb;17(1):19-29. |[2]Jin M, et al. A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia. Hum Mol Genet. 2012 Dec 15;21(26):5443-55.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P3695A/VSPPLTLGQLLS-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P3695A/
Clinical Information
No Development Reported
Curated Selection
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