CyPPA
Product Specifications
UNSPSC Description
CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels[1][2].
Target Antigen
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cyppa.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(NC2CCCCC2)=NC(N3N=C(C)C=C3C)=N1
Molecular Weight
285.39
References & Citations
[1]Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Br J Pharmacol. 2007 Jul;151(5):655-65.|[2]Dana V Skarra, et al. CyPPA, a positive modulator of small-conductance Ca(2+)-activated K(+) channels, inhibits phasic uterine contractions and delays preterm birth in mice. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1027-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W011509/CyPPA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W011509/CyPPA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
73029-73-9
Available Sizes
Curated Selection
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