(E/Z) -AG490
(E/Z) -AG490 ((E/Z) -Tyrphostin AG490) is a racemic compound of (E) -AG490 and (Z) -AG490 isomers. (E) -AG490 (HY-12000) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
Product Specifications
CAS Number
[134036-52-5]
Product Name Alternative
(E/Z) -Tyrphostin AG490; (E/Z) -Tyrphostin B42
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR; JAK; STAT
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e-z-ag490.html
Concentration
10mM
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2
Molecular Formula
C17H14N2O3
Molecular Weight
294.30
Precautions
H302, H315, H319, H335
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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