Kaempferide

Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L. Kaempferide has anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities. Kaempferide induces apoptosis. Kaempferide promotes osteogenesis through antioxidants and can be used in osteoporosis research[1][2][3][4][5][6].

Product Specifications

CAS Number

[491-54-3]

Product Name Alternative

Kaempferol 4'-O-methyl ether

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; Apoptosis; Autophagy; Bacterial; Estrogen Receptor/ERR; FOXO; GSK-3; Influenza Virus; PI3K; β-catenin

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/kaempferide.html

Concentration

10mM

Purity

99.80

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C1C(O)=C(C2=CC=C(OC)C=C2)OC3=CC(O)=CC(O)=C13

Molecular Formula

C16H12O6

Molecular Weight

300.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Chandrababu G, et al. Kaempferide exhibits an anticancer effect against hepatocellular carcinoma in vitro and in vivo[J]. Naunyn-Schmiedeberg's Archives of Pharmacology, 2023: 1-7.|[2]Tie F, et al. Kaempferol and kaempferide attenuate oleic acid-induced lipid accumulation and oxidative stress in HepG2 cells[J]. International Journal of Molecular Sciences, 2021, 22 (16) : 8847.|[3]Ma X, et al. Kaempferide enhances antioxidant capacity to promote osteogenesis through FoxO1/β-catenin signaling pathway[J]. European Journal of Pharmacology, 2021, 911: 174555.|[4]Tang H, et al. Kaempferide improves oxidative stress and inflammation by inhibiting the TLR4/IκBα/NF-κB pathway in obese mice[J]. Iranian Journal of Basic Medical Sciences, 2021, 24 (4) : 493.|[5]Wang D, et al. Kaempferide Protects against Myocardial Ischemia/Reperfusion Injury through Activation of the PI3K/Akt/GSK-3β Pathway. Mediators Inflamm. 2017;2017:5278218. |[6]Nath L R, et al. Kaempferide, the most active among the four flavonoids isolated and characterized from Chromolaena odorata, induces apoptosis in cervical cancer cells while being pharmacologically safe[J]. RSC advances, 2015, 5 (122) : 100912-100922.