BFC1108

BFC1108 is a small molecule Bcl-2 functional converter. BFC1108 induces a conformational change in Bcl-2, resulting in the exposure of its BH3 domain both in vitro and in vivo. BFC1108 effectively induces apoptosis in Bcl-2 expressing cancers.[1].

Product Specifications

CAS Number

[692774-37-1]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bfc1108.html

Concentration

10mM

Purity

98.11

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCOC1=CC=CC=C1NC(C2=CC(Cl)=CC=C2NC(C3=CC=C(OC)C=C3)=O)=O

Molecular Formula

C23H21ClN2O4

Molecular Weight

424.88

References & Citations

[1]Kopparapu PR, et al. Identification and characterization of a small molecule Bcl-2 Functional Converter. Cancer Res Commun. 2024 Feb 8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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