NiCur

NiCur is a potent and selective CBP histone acetyltransferase (HAT) inhibitor with an IC50 value of 0.35 μΜ. NiCur, which blocks CBP HAT activity and downregulates p53 activation upon genotoxic stress. NiCur can be used for performing mechanistic studies without affecting the expression of target proteins[1].

Product Specifications

CAS Number

[2674753-39-8]

UNSPSC

12352005

Target

Histone Acetyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nicur.html

Purity

99.11

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

N#CC1=CC=CC(/C=C2C(/C(CCC/2)=C/C3=CC(C#N)=CC=C3)=O)=C1

Molecular Formula

C22H16N2O

Molecular Weight

324.38

References & Citations

[1]Vincek AS, et al. Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3. Molecules. 2018;23 (8) :1930. Published 2018 Aug 2.