5-Hydroxymethyluracil

5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

Product Specifications

CAS Number

[4433-40-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/5-_Hydroxymethyl_pyrimidine-2,4_1H,3H_-dione.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1NC(C(CO)=CN1)=O

Molecular Formula

C5H6N2O3

Molecular Weight

142.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Djuric Z, et al. Quantitation of 5- (hydroxymethyl) uracil in DNA by gas chromatography with mass spectral detection. Chem Res Toxicol. 1991 Nov-Dec;4 (6) :687-91.|[2]Janoušková M, et al. 5- (Hydroxymethyl) uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase. Chem Commun (Camb) . 2017 Dec 12;53 (99) :13253-13255.