UNI418
UNI418 is a dual inhibitor of PIKfyve and PIP5K1C with antiviral activity against SARS-CoV-2 (EC50=1.4 μM) . UNI418 blocks ACE2-mediated SARS-CoV-2 viral endocytosis by inhibiting PIP5K1C (IC50=60.1 nM; Kd=61 nM) . In addition, UNI418 inhibits the proteolytic activation of proteases regulated by PIKfyve (Kd=0.78 nM) to prevent SARS-CoV-2 from entering host cells[1].
Product Specifications
CAS Number
[1802068-51-4]
UNSPSC
12352005
Target
PIKfyve; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; PI3K/Akt/mTOR
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/uni418.html
Purity
99.61
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C1(C2=CC=NC=C2)=NC(NC3=NNC(C4=CC=CC=C4)=C3)=C5C=CC=CC5=N1
Molecular Formula
C22H16N6
Molecular Weight
364.40
References & Citations
[1]Seo, et al. "A dual inhibitor of PIP5K1C and PIKfyve prevents SARS-CoV-2 entry into cells." Experimental & Molecular Medicine (2024) : 1-14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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