KR-32568

KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects[1][2].

Product Specifications

CAS Number

[852146-73-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Na+/H+ Exchanger (NHE)

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/kr-32568.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=CC=C(C(C2=CC=C(O2)C(NC(N)=N)=O)=C1)C

Molecular Formula

C13H12FN3O2

Molecular Weight

261.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Hui-Yul Roh, et al. Cardioprotective effects of [5- (2-methyl-5-fluorophenyl) furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury. Pharmacology. 2005 Dec;75 (1) :37-44. |[2]Sunkyung Lee, et al. (5-Arylfuran-2-ylcarbonyl) guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48 (8) :2882-91.