Carcinoembryonic antigen (CEA) Recombinant Antibody [Arcitumomab] (OAAV00242)
Product Specifications
Gene Name
Interleukin 18
Gene Aliases
Iboctadekin; IFN-gamma-inducing factor; IGIF; IL-1 gamma; IL-18; IL1F4; IL-1g; Interferon gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor) ; interleukin-1 gamma; interleukin-18.
Gene ID
3606
Swiss Prot
Q86UN2
Accession Number
NP_001230140.1
Reactivity
Human
Immunogen
The KLH conjugated peptide "ISTLSCENK" derived from IL-18, an augmentor of natural killer cell activity in the spleen and stimulator of interferon gamma production in Th1 cells.
Target
This is a chimeric antibody created for improved compatibility with existing reagents, assays and techniques.
Clonality
Recombinant Monoclonal
Clone
SAIC-24B-4
Type
Recombinant Monoclonal Antibody
Applications
Immunoaffinity enrichment of peptides coupled to targeted, multiple reaction monitoring mass spectrometry
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Dilution
A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable) . Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532) . Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850) .
Format
PBS with 0.02% Proclin 300.
Reconstitution
Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.
Fragment
IgG1, kappa
Specificity
Recognises human IL18.
NCBI Gene Symbol
IL18
Host or Source
Mouse
Protein Name
Interleukin-18
Gene Name URL
IL18
Nucleotide Accession Number
NM_001243211.1
Curated Selection
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