TH1020

TH1020 is a potent and selective toll-like receptor 5 (TLR5) /flagellin complex antagonist with an IC50 of 0.85 μM. TH1020 inhbits flagellin-induced TLR5 signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8[1].

Product Specifications

CAS Number

[1841460-82-9]

Product Name Alternative

SC 0030

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Bacterial; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/th1020.html

Purity

99.81

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C12=NC=NC(SC3=NN=C(N3CC4=CC=CC=C4)C5=CC=NC=C5)=C1SC6=NC=CC=C62

Molecular Formula

C23H15N7S2

Molecular Weight

453.54

Precautions

H315, H319, H320

References & Citations

[1]Lei Yan, et al. Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5) /Flagellin Complex Inhibitors. ChemMedChem. 2016 Apr 19;11 (8) :822-6.|[2]Yu Luo, et al. Toll-like Receptor 5-mediated IL-17C Expression in Intestinal Epithelial Cells Enhances Epithelial Host Defense Against F4 + ETEC Infection. Vet Res. 2019 Jun 20;50 (1) :48.