KDM4-IN-3

KDM4-IN-3 (Compound 15) is a KDM4 inhibitor (IC50 = 871 nM) that exhibits improved potency in biochemical assays. KDM4-IN-3 is cell-permeable and kills prostate cancer cells at low micro molar concentrations. KDM4-IN-3 inhibits growth of prostate cancer cell lines and increases the H3K9me3 abundance. KDM4-IN-3 can be studied in research for prostate cancer[1].

Product Specifications

CAS Number

[1068515-53-6]

UNSPSC

12352005

Target

Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kdm4-in-3.html

Purity

99.36

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

OC1=C(C2=CC=CC=C2)C(C)=NN1C3=NC4=CC=CC=C4N3

Molecular Formula

C17H14N4O

Molecular Weight

290.32

References & Citations

[1]Carter DM, et al. Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer. J Med Chem. 2021 Oct 14;64 (19) :14266-14282.