CC-99677
CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.CC-99677 in Rat experiments demonstrated potency in both biochemical (IC 50 =156.3 nM) and cellular assays (EC 50 =89 nM) .
Product Specifications
CAS Number
1887069-10-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
469.94
Molecular Formula
C22H20ClN5O3S
Notes
Research use only, not for human use.
Receptor
MAPK | HSP
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6491911-01 0.2 mL
Pantothenate Kinase 2, Mitochondrial, NT (Pantothenic Acid Kinase 2, PANK2, hPanK2, C20orf48, FLJ17232, HSS, HARP, MGC15053, NBIA1, PKAN) (APC)
Ask
View Details MBS6491911-02 5x 0.2 mL
Pantothenate Kinase 2, Mitochondrial, NT (Pantothenic Acid Kinase 2, PANK2, hPanK2, C20orf48, FLJ17232, HSS, HARP, MGC15053, NBIA1, PKAN) (APC)
Ask
View Details 