HGPR91 antagonist 1

HGPR91 antagonist 1 is a potent and selective hGPR91 antagonist (IC50: 7 μM) .GPR91, a 7TM G-Protein-Coupled Receptor, has been recently deorphanized with succinic acid as its endogenous ligand. Current literature indicates that GPR91 plays role in various pathophysiology including renal hypertension, autoimmune disease and retinal angiogenesis.