BAY-1895344
BAY-1895344 is a potent, selective, orally active ATR inhibitor with low-nanomolar potency; potently inhibits the proliferation of a broad spectrum of human tumor cell lines with mean IC50 of 78 nM; inhibits hydroxyurea-induced H2AX phosphorylation, exhibits strong in vivo anti-tumor efficacy in monotherapy in a variety of xenograft models.Blood Cancer, Phase 1 Clinical
Product Specifications
CAS Number
1876467-74-1
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
375.436
Molecular Formula
C20H21N7O
Notes
Research use only, not for human use.
Receptor
ATM/ATR
Available Sizes
Curated Selection
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