D4476

D4476 is a potent, selective and cell-permeable inhibitor of casein kinase 1 (CK1) with an IC50 value of 0.3 μM in vitro.

Product Specifications

CAS Number

[301836-43-1]

Product Name Alternative

Casein Kinase I Inhibitor

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Casein Kinase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/D4476.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(N)C1=CC=C(C=C1)C(N2)=NC(C3=CC=C4OCCOC4=C3)=C2C5=NC=CC=C5

Molecular Formula

C23H18N4O3

Molecular Weight

398.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Rena G, et al. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 2004 Jan;5 (1) :60-5.|[2]Järås M, et al. Csnk1a1 inhibition has p53-dependent therapeutic efficacy?in?acute myeloid leukemia. J Exp Med.?2014 Apr 7;211 (4) :605-12.?