(S) -PHA533533
(S) -PHA533533 is a cyclin-dependent kinase 2 (CDK2) inhibitor. (S) -PHA533533 shows anti-tumor activity and can induce widespread neuronal UBE3A expression in angelman syndrome model mice[1].
Product Specifications
CAS Number
[437982-89-3]
UNSPSC
12352211
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-pha533533.html
Concentration
10mM
Purity
98.27
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@H](C(NC1=NNC(C2CC2)=C1)=O)C3=CC=C(N4CCCC4=O)C=C3
Molecular Formula
C19H22N4O2
Molecular Weight
338.40
References & Citations
[1]Vihma H, et al. Ube3a unsilencer for the potential treatment of Angelman syndrome. Nat Commun. 2024 Jul 8;15 (1) :5558.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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