Swine CBG Recombinant Protein

The Swine CBG yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Swine CBG applications are for cell culture, ELISA standard, and Western Blot Control. Swine CBG yeast-derived recombinant protein can be purchased in multiple sizes. Swine CBG Specifications: (Molecular Weight: 17.9 kDa) (Amino Acid Sequence: EENFYVNETA TVKVPMMFQS RAMKYLNDSL LPCQLVQLEY TGNETAFFIL PVKGEMDTVI AGLSRDTIQR WSKSLIPSQV DLYVPKVSIS GAYDLGSILG DMGIVDLLSH PTHFSGITQN ALPKMSKVVH KAVLQFDEKG MEAAAPTTRG RSLHAAPKPV TVH (163) ) (Gene ID: 396736) . For research use only.

Product Specifications

Background

CBG, Corticosteroid-binding globulin, is the non-inhibitory member of the serpin superfamily of serine protease inhibitors, SERPINA6. In plasma, glucocorticoids are mainly bound to CBG, and to a lesser extent, albumin. CBG carries the vast majority of cortisol being circulated and may be involved in gender differences observed in corticosteroids circulating levels. At sites of inflammation, neutrophil activation induces the neutrophil elastase cleavage of CGB which reduces its affinity for cortisol. The cleaved form of CBG releases most of the cortisol at sites of inflammation. Plasma CBG levels are therefore involved in the adaptive stress response and play a role in maintaining equilibrium between CBG-bound and unbound cortisol.