Multi-species (Rabbit, Ferret) CXCL12 (SDF-1) Recombinant Protein

The Rabbit/Ferret CXCL12 yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Rabbit/Ferret CXCL12 applications are for cell culture, ELISA standard, and Western Blot Control. Rabbit/Ferret CXCL12 yeast-derived recombinant protein can be purchased in multiple sizes. Rabbit/Ferret CXCL12 Specifications: (Molecular Weight: 8.6 kDa) (Amino Acid Sequence: GKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKSNNRQV CIDPKLKWIQ EYLEKALNKR FKM (73) ) (Gene ID: 103345545) . For research use only.

Product Specifications

Background

CXCL12 (formerly stromal cell-derived factor 1) was originally described as a vital chemoattractant for B cells and monocytes. CXCL12 is unlike other chemokines in that it binds to one single chemokine receptor, CXCR4, which itself is recognized by no other chemokines. CXCL12 binds to its receptor CXCR4 to mediate cell-type specific physiological processes including cellular migration, survival, and apoptosis. CXCL12 is produced physiologically in various tissues and its receptor CXCR4 is also expressed on various haematopoietic and non-haematopoietic cells. CXCL12 and CXCR4 are essential for life as mice deficient in either gene are unable to survive much past birth. CXCL12 and CXCR4 play a role in many different diseases, including cancer, HIV, and rheumatoid arthritis.

Applications

Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control

Homology

Dipodomys ordii (Ord's kangaroo rat), Dipodomys spectabilis (banner-tailed kangaroo rat), Heterocephalus glaber (naked mole-rat), Mustela erminea (ermine), Mustela putorius furo (domestic ferret), Ochotona princeps (American pika), Octodon degus (degu), Oryctolagus cuniculus (rabbit), Perognathus longimembris pacificus (Pacific pocket mouse), Sciurus carolinensis (gray squirrel)