Cynomolgus Monkey Leukemia Inhibitory Factor (LIF) Polyclonal Antibody - Biotinylated

The Cynomolgus Monkey LIF polyclonal antibody is labeled and has been qualified for use in ELISA applications. It is the detection antibody in the Kingfisher Biotech Cynomolgus Monkey LIF ELISA. The Cynomolgus Monkey LIF antibody was produced in rabbits and is antigen-affinity purified. This antibody has shown to cross-react with varying degrees with other species LIF proteins. For research use only.

Product Specifications

Background

Leukemia inhibitory factor, or LIF, is a member of the IL-6 family. LIF affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate. Leukemia inhibitory factor derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells, thus preventing their continued growth. Other properties attributed to LIF include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. p53 regulated LIF has been shown to facilitate implantation in the mouse model and possibly in humans. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. LIF is typically added to stem cell culture medium to reduce spontaneous differentiation.

Host

Rabbit

Label

Biotin

Applications

ELISA, ELISpot

Purification

Antigen-affinity

Homology

Cercocebus atys (sooty mangabey), Chlorocebus sabaeus (green monkey), Colobus angolensis palliates (Angolan Colobus), Macaca fascicularis (crab-eating macaque), Macaca mulatta (Rhesus monkey), Macaca nemestrina (pig-tailed macaque), Mandrillus leucophaeus (drill), Papio anubis (olive baboon)