Mouse Oncostatin M (OSM) Polyclonal Antibody
The Mouse Oncostatin M (OSM) polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Mouse Oncostatin M ELISA. The Mouse Oncostatin M antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine OSM - None) (Canine OSM - None) (Human OSM - None) (Mouse OSM - Strong) (Swine CCL11 - None) . For research use only.
Product Specifications
Background
OSM (Oncostatin M) is a secreted cytokine involved in homeostasis and most chronic illnesses. OSM, a member of the IL-6 (gp130) family of proteins, inhibits the proliferation of a number of tumor cell lines and plays a significant role in hematopoiesis, mesenchymal stem cell differentiation, liver regeneration, heart remodeling, nociception, inflammation and metabolism. Of all IL-6-type cytokines studied so far, OSM displays the broadest signaling profile. LIF and OSM proteins activate the JAK/STAT pathway, the MAPK protein kinases ERK1 and ERK2, the stress-activated protein kinases p38 and c-Jun N-terminal kinase (JNK), the phosphatidylinositol-3-kinase (PI3K) AKT pathway and protein kinase C delta (PRKCD) . In addition, OSM exhibits many other effects by regulating the production of other cytokines including IL-6, G-CSF and GM-CSF in endothelial cells. OSM may be a tumor promoter that will provide a potential target for antiangiogenic therapy.
Host
Rabbit
Label
Unconjugated
Applications
ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
Purification
Antigen-affinity
Homology
Mus musculus (house mouse)
Storage Temperature
2°C to 8°C
Scientific Category
Antibody
Available Sizes
Curated Selection
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