Cynomolgus Monkey IL-21 Polyclonal Antibody

The Cynomolgus Monkey IL-21 polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Cynomolgus Monkey IL-21 ELISA. The Cynomolgus Monkey IL-21 antibody was produced in rabbits and is antigen-affinity purified. This antibody has shown no cross-reactivity with atlantic salmon, bat, bovine, chicken, ovine, rabbit, or swine IL-21 proteins. For research use only.

Product Specifications

Background

IL-21 is a member of the type I cytokine family, which includes IL-2 and IL-15. IL-21 signals through the common gamma-chain and a unique IL-21 receptor. The IL-21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL-21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL-21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity.