Proguanil

Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784) . Proguanil is a dihydrofolate reductase (DHFR) inhibitor[1][2].

Product Specifications

CAS Number

[500-92-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antifolate; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Proguanil.html

Purity

99.84

Solubility

DMSO : ≥ 130 mg/mL

Smiles

N=C(NC1=CC=C(Cl)C=C1)NC(NC(C)C)=N

Molecular Formula

C11H16ClN5

Molecular Weight

253.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Pudney M, et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med. 1999 May;6 Suppl 1:S8-12.|[2]Srivastava IK, et al. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother. 1999 Jun;43 (6) :1334-9.|[3]Lochner M, et al. The antimalarial drug proguanil is an antagonist at 5-HT3 receptors. J Pharmacol Exp Ther. 2014 Dec;351 (3) :674-84.|[4]Stephen AO, et al. Prolonged administration of proguanil induces reproductive toxicity in male rats. J Toxicol Sci. 2011 Oct;36 (5) :587-99.|[5]Iguchi A, et al. The in vitro interactions and in vivo efficacy of atovaquone and proguanil against Babesia gibsoni infection in dogs. Vet Parasitol. 2013 Nov 8;197 (3-4) :527-33.