Dronedarone

Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4[1].

Product Specifications

CAS Number

[141626-36-0]

Product Name Alternative

SR 33589

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Adrenergic Receptor; Autophagy; Calcium Channel; Cytochrome P450; mAChR; Sodium Channel

Type

Reference compound

Related Pathways

Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Dronedarone.html

Purity

99.93

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CCCCC1=C(C2=C(C=CC(NS(C)(=O)=O)=C2)O1)C(C3=CC=C(C=C3)OCCCN(CCCC)CCCC)=O

Molecular Formula

C31H44N2O5S

Molecular Weight

556.76

Precautions

H315, H319, H320

References & Citations

[1]Chinmay Patel, et al. Dronedarone. Circulation. 2009 Aug 18;120 (7) :636-44.|[2]Katarzyna M Sawicka, et al. Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice. J Neural Transm (Vienna) . 2019 Feb;126 (2) :115-122.