Methyldopa (hydrate)

Methyldopa hydrate (L- (-) -α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) . Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].

Product Specifications

CAS Number

[41372-08-1]

Product Name Alternative

L- (-) -α-Methyldopa (hydrate) ; MK-351 (hydrate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor; Endogenous Metabolite

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/L-_-_-_alpha_-Methyldopa-hydrate.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic)

Smiles

OC1=C(O)C=CC(C[C@@](C)(C(O)=O)N)=C1.O

Molecular Formula

C10H16NO5.5

Molecular Weight

238.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6 (5 Pt 2) :II51-II56.|[2]Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78 (3) :342-350.