SDF-1 alpha (CXCL12)
Stromal cell-derived factor (SDF) -1 alpha and SDF-1 beta are the first cytokines initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. They are encoded by a single gene, PBSF, and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the carboxy-terminus of SDF-1 beta and absent from SDF-1 alpha. SDF-1/PBSF is highly conserved between species. Human mature SDF-1 shares approximately 99% amino acid sequence identity with the mouse protein.
Product Specifications
Synonyms
Cxcl12; Sdf1
NCBI Gene ID
24772
UniProt
Q9QZD1
Accession Number
NP_071513.1
Accession Number mRNA
NM_022177.3
Chromosomal Location
4q42.1
Reactivity
Rat
Cross Reactivity
Human
Sequence
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKSNNRQVC IDPKLKWIQE YLDKALNK
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 50.0-100.0 ng/ml.
Length
68
Form
Lyophilized
Molecular Weight
7.9 kDa
Host or Source
E. coli
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