LAG-1 (CCL4L1)
LAG-1 is CC chemokine that signals through the CCR5 receptor. LAG-1 is identical to MIP-1beta (ACT II isotype) except for two amino acid substitutions; arginine for histidine at position 22 and serine for glycine at position 47 of the mature protein. LAG-1 chemoattracts monocytes, and exhibits activity as an HIV suppressive factor. Recombinant human LAG-1 is a 7.7 kDa protein containing 69 amino acid residues.
Product Specifications
Synonyms
CCL4L1; LAG1; CCL4L; LAG-1; SCYA4L; AT744.2
NCBI Gene ID
9560
UniProt
P13236
Accession Number
NP_001001435
Accession Number mRNA
NM_001001435
Chromosomal Location
100-234
Reactivity
Human
Cross Reactivity
Human
Sequence
APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 90% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by it's ability to chemoattract CCR5 transfected cells using a concentration of 0.1-10.0 ng/ml
Length
69
Form
Lyophilized
Molecular Weight
7.7 kDa
Host or Source
E. coli
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