JE (MCP-1, CCL2)
The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross reacts across species. Recombinant murine JE is a 13.8 kDa protein containing 125 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Product Specifications
Synonyms
Ccl2; JE; HC11; MCAF; MCP1; MCP-1; Scya2; Sigje; SMC-CF; AI323594
NCBI Gene ID
20296
UniProt
P10148
Accession Number
NP_035463.1
Accession Number mRNA
NM_011333.3
Chromosomal Location
11 C-E1; 11 46.5 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse, Rabbit, Monkey, Bacteria
Sequence
QPDAVNAPLT CCYSFTSKMI PMSRLESYKR ITSSRCPKEA VVFVTKLKRE VCADPKKEWV QTYIKNLDRN QMRSEPTTLF KTASALRSSA PLNVKLTRKS EANASTTFST TTSSTSVGVT SVTVN
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract Balb/C mouse spleen MNCs using a concentration range of 1.0-20.0 ng/ml.
Length
125
Form
Lyophilized
Molecular Weight
13.8 kDa
Host or Source
E. coli
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